Challenging the “chromatin hypothesis” of cardiac laminopathies with LMNA mutant iPS cells

Lamins A and C are intermediate filaments that provide structural support to the nuclear envelope and regulate gene expression. In this issue, Bertero et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902117) report that although lamin A/C haploinsufficient cardiomyocytes show disease-assoc...

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Detalles Bibliográficos
Autores principales: Mozzetta, Chiara, Tedesco, Francesco Saverio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719444/
https://www.ncbi.nlm.nih.gov/pubmed/31427369
http://dx.doi.org/10.1083/jcb.201907166
Descripción
Sumario:Lamins A and C are intermediate filaments that provide structural support to the nuclear envelope and regulate gene expression. In this issue, Bertero et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902117) report that although lamin A/C haploinsufficient cardiomyocytes show disease-associated phenotypes, those changes cannot be explained by alterations in chromatin compartmentalization.

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