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Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy

Mutations in A-type nuclear lamins cause dilated cardiomyopathy, which is postulated to result from dysregulated gene expression due to changes in chromatin organization into active and inactive compartments. To test this, we performed genome-wide chromosome conformation analyses in human induced pl...

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Detalles Bibliográficos
Autores principales: Bertero, Alessandro, Fields, Paul A., Smith, Alec S.T., Leonard, Andrea, Beussman, Kevin, Sniadecki, Nathan J., Kim, Deok-Ho, Tse, Hung-Fat, Pabon, Lil, Shendure, Jay, Noble, William S., Murry, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719452/
https://www.ncbi.nlm.nih.gov/pubmed/31395619
http://dx.doi.org/10.1083/jcb.201902117