SNX3 drives maturation of Borrelia phagosomes by forming a hub for PI(3)P, Rab5a, and galectin-9

The spirochete Borrelia burgdorferi, the causative agent of Lyme disease, is internalized by macrophages and processed in phagolysosomes. Phagosomal compaction, a crucial step in phagolysosome maturation, is driven by contact of Rab5a-positive vesicles with the phagosomal coat. We show that the sort...

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Detalles Bibliográficos
Autores principales: Klose, Matthias, Salloum, Johann E., Gonschior, Hannes, Linder, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719455/
https://www.ncbi.nlm.nih.gov/pubmed/31337623
http://dx.doi.org/10.1083/jcb.201812106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719455/
https://www.ncbi.nlm.nih.gov/pubmed/31337623
http://dx.doi.org/10.1083/jcb.201812106

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