Nxf3: a middleman with the right connections for unspliced piRNA precursor export

RNA export is tightly coupled to splicing in metazoans. In the Drosophila germline, precursors for the majority of Piwi-interacting RNAs (piRNAs) are unspliced. In this issue of Genes & Development, Kneuss and colleagues (pp. 1208–1220) identify Nxf3 as a novel germline-specific export adapter f...

Descripción completa

Detalles Bibliográficos
Autores principales: Mendel, Mateusz, Pillai, Ramesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719615/
https://www.ncbi.nlm.nih.gov/pubmed/31481534
http://dx.doi.org/10.1101/gad.330530.119
Descripción
Sumario:RNA export is tightly coupled to splicing in metazoans. In the Drosophila germline, precursors for the majority of Piwi-interacting RNAs (piRNAs) are unspliced. In this issue of Genes & Development, Kneuss and colleagues (pp. 1208–1220) identify Nxf3 as a novel germline-specific export adapter for such unspliced transcripts. Their findings reveal the sequence of events leading from its role at the site of transcription to delivery of the cargo to cytoplasmic piRNA biogenesis sites.

Ejemplares similares