Nxf3: a middleman with the right connections for unspliced piRNA precursor export

RNA export is tightly coupled to splicing in metazoans. In the Drosophila germline, precursors for the majority of Piwi-interacting RNAs (piRNAs) are unspliced. In this issue of Genes & Development, Kneuss and colleagues (pp. 1208–1220) identify Nxf3 as a novel germline-specific export adapter f...

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Detalles Bibliográficos
Autores principales: Mendel, Mateusz, Pillai, Ramesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719615/
https://www.ncbi.nlm.nih.gov/pubmed/31481534
http://dx.doi.org/10.1101/gad.330530.119
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author Mendel, Mateusz
Pillai, Ramesh S.
author_facet Mendel, Mateusz
Pillai, Ramesh S.
author_sort Mendel, Mateusz
collection PubMed
description RNA export is tightly coupled to splicing in metazoans. In the Drosophila germline, precursors for the majority of Piwi-interacting RNAs (piRNAs) are unspliced. In this issue of Genes & Development, Kneuss and colleagues (pp. 1208–1220) identify Nxf3 as a novel germline-specific export adapter for such unspliced transcripts. Their findings reveal the sequence of events leading from its role at the site of transcription to delivery of the cargo to cytoplasmic piRNA biogenesis sites.
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spelling pubmed-67196152020-03-01 Nxf3: a middleman with the right connections for unspliced piRNA precursor export Mendel, Mateusz Pillai, Ramesh S. Genes Dev Outlook RNA export is tightly coupled to splicing in metazoans. In the Drosophila germline, precursors for the majority of Piwi-interacting RNAs (piRNAs) are unspliced. In this issue of Genes & Development, Kneuss and colleagues (pp. 1208–1220) identify Nxf3 as a novel germline-specific export adapter for such unspliced transcripts. Their findings reveal the sequence of events leading from its role at the site of transcription to delivery of the cargo to cytoplasmic piRNA biogenesis sites. Cold Spring Harbor Laboratory Press 2019-09-01 /pmc/articles/PMC6719615/ /pubmed/31481534 http://dx.doi.org/10.1101/gad.330530.119 Text en © 2019 Mendel and Pillai; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Mendel, Mateusz
Pillai, Ramesh S.
Nxf3: a middleman with the right connections for unspliced piRNA precursor export
title Nxf3: a middleman with the right connections for unspliced piRNA precursor export
title_full Nxf3: a middleman with the right connections for unspliced piRNA precursor export
title_fullStr Nxf3: a middleman with the right connections for unspliced piRNA precursor export
title_full_unstemmed Nxf3: a middleman with the right connections for unspliced piRNA precursor export
title_short Nxf3: a middleman with the right connections for unspliced piRNA precursor export
title_sort nxf3: a middleman with the right connections for unspliced pirna precursor export
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719615/
https://www.ncbi.nlm.nih.gov/pubmed/31481534
http://dx.doi.org/10.1101/gad.330530.119
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