Max deletion destabilizes MYC protein and abrogates Eµ-Myc lymphomagenesis

Although MAX is regarded as an obligate dimerization partner for MYC, its function in normal development and neoplasia is poorly defined. We show that B-cell-specific deletion of Max has a modest effect on B-cell development but completely abrogates Eµ-Myc-driven lymphomagenesis. While Max loss affe...

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Detalles Bibliográficos
Autores principales: Mathsyaraja, Haritha, Freie, Brian, Cheng, Pei-Feng, Babaeva, Ekaterina, Catchpole, Jonathen T., Janssens, Derek, Henikoff, Steven, Eisenman, Robert N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719623/
https://www.ncbi.nlm.nih.gov/pubmed/31395740
http://dx.doi.org/10.1101/gad.325878.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719623/
https://www.ncbi.nlm.nih.gov/pubmed/31395740
http://dx.doi.org/10.1101/gad.325878.119

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