PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells

The patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) I148M variant predisposes to hepatic steatosis and progression to advanced liver injury with development of fibrosis, cirrhosis, and cancer. Hepatic stellate cells (HSCs) drive the wound healing response to chronic injury, and lack...

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Detalles Bibliográficos
Autores principales: Bruschi, Francesca Virginia, Claudel, Thierry, Tardelli, Matteo, Starlinger, Patrick, Marra, Fabio, Trauner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719741/
https://www.ncbi.nlm.nih.gov/pubmed/31497741
http://dx.doi.org/10.1002/hep4.1395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719741/
https://www.ncbi.nlm.nih.gov/pubmed/31497741
http://dx.doi.org/10.1002/hep4.1395

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