LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors

Self-renewing somatic tissues depend upon the proper balance of chromatin-modifying enzymes to coordinate progenitor cell maintenance and differentiation, disruption of which can promote carcinogenesis. As a result, drugs targeting the epigenome hold significant therapeutic potential. The histone de...

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Detalles Bibliográficos
Autores principales: Egolf, Shaun, Aubert, Yann, Doepner, Miriam, Anderson, Amy, Maldonado-Lopez, Alexandra, Pacella, Gina, Lee, Jessica, Ko, Eun Kyung, Zou, Jonathan, Lan, Yemin, Simpson, Cory L., Ridky, Todd, Capell, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719800/
https://www.ncbi.nlm.nih.gov/pubmed/31433976
http://dx.doi.org/10.1016/j.celrep.2019.07.058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719800/
https://www.ncbi.nlm.nih.gov/pubmed/31433976
http://dx.doi.org/10.1016/j.celrep.2019.07.058

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