Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient

Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report a 65-year-old female with rectal adenocarcinoma who experienced severe toxicities secondary to standard dose 5-FU based chemotherapy. She was found to be heter...

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Detalles Bibliográficos
Autores principales: Bukhari, Nedal, Azam, Faisal, Alfawaz, Mohammed, Zahrani, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720358/
https://www.ncbi.nlm.nih.gov/pubmed/31531249
http://dx.doi.org/10.1155/2019/5150725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720358/
https://www.ncbi.nlm.nih.gov/pubmed/31531249
http://dx.doi.org/10.1155/2019/5150725

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