Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples

BACKGROUND: Archived formalin fixed paraffin embedded (FFPE) samples are valuable clinical resources to examine clinically relevant morphology features and also to study genetic changes. However, DNA quality and quantity of FFPE samples are often sub-optimal, and resulting NGS-based genetics variant...

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Detalles Bibliográficos
Autores principales: Bhagwate, Aditya Vijay, Liu, Yuanhang, Winham, Stacey J., McDonough, Samantha J., Stallings-Mann, Melody L., Heinzen, Ethan P., Davila, Jaime I., Vierkant, Robert A., Hoskin, Tanya L., Frost, Marlene, Carter, Jodi M., Radisky, Derek C., Cunningham, Julie M., Degnim, Amy C., Wang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720378/
https://www.ncbi.nlm.nih.gov/pubmed/31477010
http://dx.doi.org/10.1186/s12864-019-6056-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720378/
https://www.ncbi.nlm.nih.gov/pubmed/31477010
http://dx.doi.org/10.1186/s12864-019-6056-8

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