Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear. Here, we show that FBP-unoccupied aldolase interacts with and inhibits e...

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Detalles Bibliográficos
Autores principales: Li, Mengqi, Zhang, Chen-Song, Zong, Yue, Feng, Jin-Wei, Ma, Teng, Hu, Meiqin, Lin, Zhizhong, Li, Xiaotong, Xie, Changchuan, Wu, Yaying, Jiang, Dong, Li, Ying, Zhang, Cixiong, Tian, Xiao, Wang, Wen, Yang, Yanyan, Chen, Jie, Cui, Jiwen, Wu, Yu-Qing, Chen, Xin, Liu, Qing-Feng, Wu, Jianfeng, Lin, Shu-Yong, Ye, Zhiyun, Liu, Ying, Piao, Hai-Long, Yu, Li, Zhou, Zhuan, Xie, Xiao-Song, Hardie, D. Grahame, Lin, Sheng-Cai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720459/
https://www.ncbi.nlm.nih.gov/pubmed/31204282
http://dx.doi.org/10.1016/j.cmet.2019.05.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720459/
https://www.ncbi.nlm.nih.gov/pubmed/31204282
http://dx.doi.org/10.1016/j.cmet.2019.05.018

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