RNA Secondary Structure-Based Design of Antisense Peptide Nucleic Acids for Modulating Disease-Associated Aberrant Tau Pre-mRNA Alternative Splicing

Alternative splicing of tau pre-mRNA is regulated by a 5′ splice site (5′ss) hairpin present at the exon 10–intron 10 junction. Single mutations within the hairpin sequence alter hairpin structural stability and/or the binding of splicing factors, resulting in disease-causing aberrant splicing of ex...

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Detalles Bibliográficos
Autores principales: Ong, Alan Ann Lerk, Tan, Jiazi, Bhadra, Malini, Dezanet, Clément, Patil, Kiran M., Chong, Mei Sian, Kierzek, Ryszard, Decout, Jean-Luc, Roca, Xavier, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720520/
https://www.ncbi.nlm.nih.gov/pubmed/31434312
http://dx.doi.org/10.3390/molecules24163020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720520/
https://www.ncbi.nlm.nih.gov/pubmed/31434312
http://dx.doi.org/10.3390/molecules24163020

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