Impact of the Position of the Chemically Modified 5-Furyl-2′-Deoxyuridine Nucleoside on the Thrombin DNA Aptamer–Protein Complex: Structural Insights into Aptamer Response from MD Simulations

Aptamers are functional nucleic acids that bind to a range of targets (small molecules, proteins or cells) with a high affinity and specificity. Chemically-modified aptamers are of interest because the incorporation of novel nucleobase components can enhance aptamer binding to target proteins, while...

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Detalles Bibliográficos
Autores principales: Seelam Prabhakar, Preethi, A. Manderville, Richard, D. Wetmore, Stacey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720718/
https://www.ncbi.nlm.nih.gov/pubmed/31405145
http://dx.doi.org/10.3390/molecules24162908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720718/
https://www.ncbi.nlm.nih.gov/pubmed/31405145
http://dx.doi.org/10.3390/molecules24162908

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