Design, Synthesis, and Biological Evaluation of Novel N-Acylhydrazone Bond Linked Heterobivalent β-Carbolines as Potential Anticancer Agents

Utilizing a pharmacophore hybridization approach, we have designed and synthesized a novel series of 28 new heterobivalent β-carbolines. The in vitro cytotoxic potential of each compound was evaluated against the five cancer cell lines (LLC, BGC-823, CT-26, Bel-7402, and MCF-7) of different origin—m...

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Detalles Bibliográficos
Autores principales: Chen, Xiaofei, Guo, Liang, Ma, Qin, Chen, Wei, Fan, Wenxi, Zhang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720801/
https://www.ncbi.nlm.nih.gov/pubmed/31416271
http://dx.doi.org/10.3390/molecules24162950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720801/
https://www.ncbi.nlm.nih.gov/pubmed/31416271
http://dx.doi.org/10.3390/molecules24162950

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