The Cyclooxigenase-2 Inhibitor Parecoxib Prevents Epidermal Dysplasia in HPV16-Transgenic Mice: Efficacy and Safety Observations

Carcinogenesis induced by high-risk human papillomavirus (HPV) involves inflammatory phenomena, partially mediated by cyclooxigenase-2. In pre-clinical models of HPV-induced cancer, cyclooxygenase-2 inhibitors have shown significant efficacy, but also considerable toxicity. This study addresses the...

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Detalles Bibliográficos
Autores principales: Ferreira, Tiago, Campos, Sandra, Silva, Mónica G., Ribeiro, Rita, Santos, Susana, Almeida, José, Pires, Maria João, Gil da Costa, Rui Miguel, Córdova, Cláudia, Nogueira, António, Neuparth, Maria João, Medeiros, Rui, Monteiro Bastos, Margarida Maria da Silva, Gaivão, Isabel, Peixoto, Francisco, Oliveira, Maria Manuel, Oliveira, Paula Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720853/
https://www.ncbi.nlm.nih.gov/pubmed/31405112
http://dx.doi.org/10.3390/ijms20163902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720853/
https://www.ncbi.nlm.nih.gov/pubmed/31405112
http://dx.doi.org/10.3390/ijms20163902

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