Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants

Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about the safety of heparin, since in 2008, adverse effects associated with the presence of an oversulfated chondroitin sulfate (OSCS) were observed in prepara...

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Detalles Bibliográficos
Autores principales: Mendes, Aline, Meneghetti, Maria C. Z., Palladino, Marcelly Valle, Justo, Giselle Zenker, Sassaki, Guilherme L., Fareed, Jawed, Lima, Marcelo A., Nader, Helena B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721129/
https://www.ncbi.nlm.nih.gov/pubmed/31426507
http://dx.doi.org/10.3390/molecules24162988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721129/
https://www.ncbi.nlm.nih.gov/pubmed/31426507
http://dx.doi.org/10.3390/molecules24162988

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