Cargando…

Structural Consequences of Copper Binding to the Prion Protein

Prion, or PrP(Sc), is the pathological isoform of the cellular prion protein (PrP(C)) and it is the etiological agent of transmissible spongiform encephalopathies (TSE) affecting humans and animal species. The most relevant function of PrP(C) is its ability to bind copper ions through its flexible N...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salzano, Giulia, Giachin, Gabriele, Legname, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721516/ https://www.ncbi.nlm.nih.gov/pubmed/31349611 http://dx.doi.org/10.3390/cells8080770

Ejemplares similares

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion
por: Giachin, Gabriele, et al.
Publicado: (2015)

Unique Structural Features of Mule Deer Prion Protein Provide Insights into Chronic Wasting Disease
por: Slapšak, Urška, et al.
Publicado: (2019)

In vitro aggregation assays for the characterization of α-synuclein prion-like properties
por: Narkiewicz, Joanna, et al.
Publicado: (2014)

Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy
por: Giachin, Gabriele, et al.
Publicado: (2013)

Copper coordination modulates prion conversion and infectivity in mammalian prion proteins
por: Legname, Giuseppe
Publicado: (2023)

Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion
por: Abskharon, Romany, et al.
Publicado: (2019)

Structural and dynamical determinants of a β-sheet-enriched intermediate involved in amyloid fibrillar assembly of human prion protein
por: Russo, Luigi, et al.
Publicado: (2022)

NMR Structure of the Human Prion Protein with the Pathological Q212P Mutation Reveals Unique Structural Features
por: Ilc, Gregor, et al.
Publicado: (2010)

Prion Protein Interaction with Soil Humic Substances: Environmental Implications
por: Giachin, Gabriele, et al.
Publicado: (2014)

Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy
por: Raspadori, Andrea, et al.
Publicado: (2022)

In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution
por: Gasperini, Lisa, et al.
Publicado: (2016)

The mechanisms of humic substances self-assembly with biological molecules: The case study of the prion protein
por: Giachin, Gabriele, et al.
Publicado: (2017)

Elucidating the function of the prion protein
por: Legname, Giuseppe
Publicado: (2017)

Prion protein and aging
por: Gasperini, Lisa, et al.
Publicado: (2014)

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in Neurodegeneration
por: Scialò, Carlo, et al.
Publicado: (2019)

New insights into structural determinants of prion protein folding and stability
por: Benetti, Federico, et al.
Publicado: (2015)

A novel expression system for production of soluble prion proteins in E. coli
por: Abskharon, Romany NN, et al.
Publicado: (2012)

Prion Protein and Copper Cooperatively Protect Neurons by Modulating NMDA Receptor Through S-nitrosylation
por: Gasperini, Lisa, et al.
Publicado: (2015)

Prion Protein-Specific Antibodies-Development, Modes of Action and Therapeutics Application
por: Rovis, Tihana Lenac, et al.
Publicado: (2014)

On the role of the cellular prion protein in the uptake and signaling of pathological aggregates in neurodegenerative diseases
por: Legname, Giuseppe, et al.
Publicado: (2020)

De novo prions
por: Benetti, Federico, et al.
Publicado: (2010)

Recognition Mechanisms between a Nanobody and Disordered Epitopes of the Human Prion Protein: An Integrative Molecular Dynamics Study
por: Mollica, Luca, et al.
Publicado: (2022)

Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions
por: Sánchez-López, Carolina, et al.
Publicado: (2018)

Mapping the Prion Protein Distribution in Marsupials: Insights from Comparing Opossum with Mouse CNS
por: Poggiolini, Ilaria, et al.
Publicado: (2012)

Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids
por: Bistaffa, Edoardo, et al.
Publicado: (2019)

Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance
por: Colini Baldeschi, Arianna, et al.
Publicado: (2022)

Prion Protein Accumulation in Lipid Rafts of Mouse Aging Brain
por: Agostini, Federica, et al.
Publicado: (2013)

Detection of prion seeding activity in the olfactory mucosa of patients with Fatal Familial Insomnia
por: Redaelli, Veronica, et al.
Publicado: (2017)

Copper-induced structural conversion templates prion protein oligomerization and neurotoxicity
por: Yen, Chi-Fu, et al.
Publicado: (2016)

Investigating the Conformational Stability of Prion Strains through a Kinetic Replication Model
por: Zampieri, Mattia, et al.
Publicado: (2009)

Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene
por: Di Fede, Giuseppe, et al.
Publicado: (2019)

Astrocytes‐derived extracellular vesicles in motion at the neuron surface: Involvement of the prion protein
por: D'Arrigo, Giulia, et al.
Publicado: (2021)

Calorimetric Investigation of Copper Binding in the N-Terminal Region of the Prion Protein at Low Copper Loading: Evidence for an Entropically Favorable First Binding Event
por: Gogineni, Devi Praneetha, et al.
Publicado: (2014)

The Cellular Prion Protein Increases the Uptake and Toxicity of TDP-43 Fibrils
por: Scialò, Carlo, et al.
Publicado: (2021)

Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction
por: Miranzadeh Mahabadi, Hajar, et al.
Publicado: (2020)

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication
por: Aulić, Suzana, et al.
Publicado: (2017)

Pharmacokinetics of quinacrine in the treatment of prion disease
por: Yung, Lotus, et al.
Publicado: (2004)

PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice
por: Bistaffa, Edoardo, et al.
Publicado: (2021)

Solvent Microenvironments and Copper Binding Alters the Conformation and Toxicity of a Prion Fragment
por: Inayathullah, Mohammed, et al.
Publicado: (2013)

Metabolism of minor isoforms of prion proteins: Cytosolic prion protein and transmembrane prion protein
por: Song, Zhiqi, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_9c91omatudejhvc4gjtm322kac