Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity

Cholinergic dysfunction in Alzheimer’s disease (AD) can be mediated by the neuronal α7 nicotinic acetylcholine receptor (α7nAChR). Beta-amyloid peptide (Aβ) binds to the α7nAChR, disrupting the receptor’s function and causing neurotoxicity. In vivo not only Aβ but also its modified forms can drive A...

Descripción completa

Detalles Bibliográficos
Autores principales: Barykin, Evgeny P., Garifulina, Alexandra I., Kruykova, Elena V., Spirova, Ekaterina N., Anashkina, Anastasia A., Adzhubei, Alexei A., Shelukhina, Irina V., Kasheverov, Igor E., Mitkevich, Vladimir A., Kozin, Sergey A., Hollmann, Michael, Tsetlin, Victor I., Makarov, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721525/
https://www.ncbi.nlm.nih.gov/pubmed/31349637
http://dx.doi.org/10.3390/cells8080771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721525/
https://www.ncbi.nlm.nih.gov/pubmed/31349637
http://dx.doi.org/10.3390/cells8080771

Ejemplares similares