SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

Half of human cancers harbor TP53 mutations that render p53 inactive as a tumor suppressor. In these cancers, reactivation of mutant p53 (mutp53) through restoration of wild-type-like function constitutes a valuable anticancer therapeutic strategy. In order to search for mutp53 reactivators, a small...

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Detalles Bibliográficos
Autores principales: Gomes, Sara, Bosco, Bartolomeo, Loureiro, Joana B., Ramos, Helena, Raimundo, Liliana, Soares, Joana, Nazareth, Nair, Barcherini, Valentina, Domingues, Lucília, Oliveira, Carla, Bisio, Alessandra, Piazza, Silvano, Bauer, Matthias R., Brás, João P., Almeida, Maria Inês, Gomes, Célia, Reis, Flávio, Fersht, Alan R., Inga, Alberto, Santos, Maria M. M., Saraiva, Lucília
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721528/
https://www.ncbi.nlm.nih.gov/pubmed/31405179
http://dx.doi.org/10.3390/cancers11081151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721528/
https://www.ncbi.nlm.nih.gov/pubmed/31405179
http://dx.doi.org/10.3390/cancers11081151

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