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Mutation in DNA Polymerase Beta Causes Spontaneous Chromosomal Instability and Inflammation-Associated Carcinogenesis in Mice

DNA polymerase beta (Pol β) is a key enzyme in the base excision repair (BER) pathway. Pol β is mutated in approximately 40% of human tumors in small-scale studies. The 5´-deoxyribose-5-phosphate (dRP) lyase domain of Pol β is responsible for DNA end tailoring to remove the 5’ phosphate group. We pr...

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Detalles Bibliográficos
Autores principales: Zhao, Shengyuan, Klattenhoff, Alex W., Thakur, Megha, Sebastian, Manu, Kidane, Dawit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721533/
https://www.ncbi.nlm.nih.gov/pubmed/31412651
http://dx.doi.org/10.3390/cancers11081160