Cargando…

Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer

Epigenetic alterations play a central role in cancer development and progression. The acetylation of histone 3 at lysine 27 (H3K27ac) specifically marks active genes. While chromatin immunoprecipitation (ChIP) followed by next-generation sequencing (ChIP-seq) analyses are commonly performed in cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Flebbe, Hannah, Hamdan, Feda H., Kari, Vijayalakshmi, Kitz, Julia, Gaedcke, Jochen, Ghadimi, B. Michael, Johnsen, Steven A., Grade, Marian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721540/ https://www.ncbi.nlm.nih.gov/pubmed/31404997 http://dx.doi.org/10.3390/cancers11081142

Ejemplares similares

The molecular basis of chemoradiosensitivity in rectal cancer:implications for personalized therapies
por: Grade, Marian, et al.
Publicado: (2012)

Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer
por: Azizian, Azadeh, et al.
Publicado: (2016)

Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer
por: Gaedcke, Jochen, et al.
Publicado: (2014)

Heterogeneity of KRAS Mutation Status in Rectal Cancer
por: Jo, Peter, et al.
Publicado: (2016)

Targeting STAT3 Signaling Facilitates Responsiveness of Pancreatic Cancer Cells to Chemoradiotherapy
por: Flebbe, Hannah, et al.
Publicado: (2022)

KRAS mutation status concordance between the primary tumor and the corresponding metastasis in patients with rectal cancer
por: Jo, Peter, et al.
Publicado: (2020)

Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies
por: Jo, Peter, et al.
Publicado: (2016)

Gene-expression profiles of pretreatment biopsies predict complete response of rectal cancer patients to preoperative chemoradiotherapy
por: Emons, Georg, et al.
Publicado: (2022)

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness
por: Kari, Vijayalakshmi, et al.
Publicado: (2019)

Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy
por: Jo, Peter, et al.
Publicado: (2017)

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites
por: Patzak, Melanie S., et al.
Publicado: (2019)

ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells
por: Sen, Madhobi, et al.
Publicado: (2019)

Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal Carcinomas
por: Ghadimi, B. Michael, et al.
Publicado: (2006)

Pelvic intraoperative neuromonitoring during robotic-assisted low anterior resection for rectal cancer
por: Grade, Marian, et al.
Publicado: (2015)

Impact of RNA degradation on gene expression profiling
por: Opitz, Lennart, et al.
Publicado: (2010)

Impact of Portal Vein Resection (PVR) in Patients Who Underwent Curative Intended Pancreatic Head Resection
por: Bernhardt, Markus, et al.
Publicado: (2023)

Perturbing Enhancer Activity in Cancer Therapy
por: Hamdan, Feda H., et al.
Publicado: (2019)

Personalmanagement und Leadership in der Chirurgie
por: Grade, Marian, et al.
Publicado: (2021)

NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy
por: Koerdel, Kristin, et al.
Publicado: (2021)

The mesopancreas is the primary site for R1 resection in pancreatic head cancer: relevance for clinical trials
por: Gaedcke, J., et al.
Publicado: (2009)

Store-Operated Calcium Entry: Shaping the Transcriptional and Epigenetic Landscape in Pancreatic Cancer
por: Kutschat, Ana P., et al.
Publicado: (2021)

Standard perioperative management in gastrointestinal surgery
por: Grade, Marian, et al.
Publicado: (2011)

The Impact of Molecular Pathology in Oncology: The Clinician’s Perspective
por: Grade, Marian, et al.
Publicado: (2004)

Combined targeting of HER-2 and HER-3 represents a promising therapeutic strategy in colorectal cancer
por: Conradi, Lena-Christin, et al.
Publicado: (2019)

The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells
por: Schneider, Deborah, et al.
Publicado: (2019)

ATRT-07. DEFINING LOST AND GAINED TRANSCRIPTIONAL REGULATORY NETWORKS IN ATYPICAL TERATOID RHABDOID TUMOR
por: Nesvick, Cody, et al.
Publicado: (2021)

Effectiveness of fourth-line dual immunotherapy in hepatocellular carcinoma with simultaneous steroid administration for immune-related hepatitis
por: Lowes, Kristina, et al.
Publicado: (2022)

Cure Is Possible: Extensively Metastatic HER2-Positive Gastric Carcinoma with 5 years of Complete Remission after Therapy with the FLOT Regimen and Trastuzumab
por: Schade, Sebastian, et al.
Publicado: (2022)

UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib
por: Landmann, H, et al.
Publicado: (2014)

Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks
por: Rendeiro, André F., et al.
Publicado: (2016)

Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact
por: Grade, Marian, et al.
Publicado: (2006)

A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells
por: Wolff, Alexander, et al.
Publicado: (2018)

Correction: A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells
por: Wolff, Alexander, et al.
Publicado: (2019)

Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies
por: Patkar, Sushant, et al.
Publicado: (2021)

Cell-specific histone modification maps link schizophrenia risk to the neuronal epigenome
por: Girdhar, Kiran, et al.
Publicado: (2018)

BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells
por: Nagarajan, Sankari, et al.
Publicado: (2017)

STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy
por: Spitzner, Melanie, et al.
Publicado: (2014)

CpG Island Mapping by Epigenome Prediction
por: Bock, Christoph, et al.
Publicado: (2007)

The comprehensive epigenome map of piRNA clusters
por: Kawaoka, Shinpei, et al.
Publicado: (2013)

Chromosome-specific maturation of the epigenome in the Drosophila male germline
por: Anderson, James, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dj718161uiorq2svrnsofumvaj