Destabilization of Eukaryote mRNAs by 5′ Proximal Stop Codons Can Occur Independently of the Nonsense-Mediated mRNA Decay Pathway

In eukaryotes, the binding of poly(A) binding protein (PAB) to the poly(A) tail is central to maintaining mRNA stability. PABP interacts with the translation termination apparatus, and with eIF4G to maintain 3′–5′ mRNA interactions as part of an mRNA closed loop. It is however unclear how ribosome r...

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Detalles Bibliográficos
Autores principales: Gorgoni, Barbara, Zhao, Yun-Bo, Krishnan, J., Stansfield, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721604/
https://www.ncbi.nlm.nih.gov/pubmed/31370247
http://dx.doi.org/10.3390/cells8080800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721604/
https://www.ncbi.nlm.nih.gov/pubmed/31370247
http://dx.doi.org/10.3390/cells8080800

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