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Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model

Gasdermin E (GSDME), also known as deafness autosomal dominant 5 (DFNA5) and previously identified to be an inducer of regulated cell death, is frequently epigenetically inactivated in different cancer types, suggesting that GSDME is a tumor suppressor gene. In this study, we aimed to evaluate the t...

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Detalles Bibliográficos
Autores principales: Croes, Lieselot, Fransen, Erik, Hylebos, Marieke, Buys, Kimberly, Hermans, Christophe, Broeckx, Glenn, Peeters, Marc, Pauwels, Patrick, Op de Beeck, Ken, Van Camp, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721630/
https://www.ncbi.nlm.nih.gov/pubmed/31434357
http://dx.doi.org/10.3390/cancers11081214