Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation

Lipoic acid (LA) is a redox-active disulphide compound, which functions as a pivotal co-factor for mitochondrial oxidative decarboxylation. LA and chemical derivatives were shown to target mitochondria in cancer cells with altered energy metabolism, thereby inducing cell death. In this study, the im...

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Detalles Bibliográficos
Autores principales: Neitzel, Carina, Seiwert, Nina, Göder, Anja, Diehl, Erika, Weber, Carina, Nagel, Georg, Stroh, Svenja, Rasenberger, Birgit, Christmann, Markus, Fahrer, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721634/
https://www.ncbi.nlm.nih.gov/pubmed/31366086
http://dx.doi.org/10.3390/cells8080794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721634/
https://www.ncbi.nlm.nih.gov/pubmed/31366086
http://dx.doi.org/10.3390/cells8080794

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