Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity

Fibroblast growth factor 1 (FGF1) has been shown to interact with integrin α(v)β(3) through a specific binding site, involving Arg35 residue. The FGF1 mutant (R35E) with impaired integrin binding was found to be defective in its proliferative response, although it was still able to interact with FGF...

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Detalles Bibliográficos
Autores principales: Szlachcic, Anna, Sochacka, Martyna, Czyrek, Aleksandra, Opalinski, Lukasz, Krowarsch, Daniel, Otlewski, Jacek, Zakrzewska, Malgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721657/
https://www.ncbi.nlm.nih.gov/pubmed/31443196
http://dx.doi.org/10.3390/cells8080899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721657/
https://www.ncbi.nlm.nih.gov/pubmed/31443196
http://dx.doi.org/10.3390/cells8080899

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