iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation

Background: Group VIA calcium-independent phospholipase A2 (iPla2β) regulates homeostasis and remodeling of phospholipids (PL). We previously showed that iPla2β(−/−) mice fed with a methionine-choline-deficient diet (MCD) exhibited exaggerated liver fibrosis. As iPla2β is located in the endoplasmic...

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Detalles Bibliográficos
Autores principales: Ming, Yanan, Zhu, Xingya, Tuma-Kellner, Sabine, Ganzha, Alexandra, Liebisch, Gerhard, Gan-Schreier, Hongying, Chamulitrat, Walee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721660/
https://www.ncbi.nlm.nih.gov/pubmed/31409057
http://dx.doi.org/10.3390/cells8080879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721660/
https://www.ncbi.nlm.nih.gov/pubmed/31409057
http://dx.doi.org/10.3390/cells8080879

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