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Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies
Aging is associated with multiple molecular and functional changes in haematopoietic cells. Most notably, the self-renewal and differentiation potential of hematopoietic stem cells (HSCs) are compromised, resulting in myeloid skewing, reduced output of red blood cells and decreased generation of imm...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721661/ https://www.ncbi.nlm.nih.gov/pubmed/31405121 http://dx.doi.org/10.3390/cells8080868 |