The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage

Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs. Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-ter...

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Detalles Bibliográficos
Autores principales: Duan, Tian-Li, He, Guang-Jun, Hu, Li-Dan, Yan, Yong-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721724/
https://www.ncbi.nlm.nih.gov/pubmed/31387300
http://dx.doi.org/10.3390/cells8080836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721724/
https://www.ncbi.nlm.nih.gov/pubmed/31387300
http://dx.doi.org/10.3390/cells8080836

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