Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody–DM1 Drug Conjugates

Affibody molecules are small affinity-engineered scaffold proteins which can be engineered to bind to desired targets. The therapeutic potential of using an affibody molecule targeting HER2, fused to an albumin-binding domain (ABD) and conjugated with the cytotoxic maytansine derivate MC-DM1 (AffiDC...

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Detalles Bibliográficos
Autores principales: Ding, Haozhong, Altai, Mohamed, Rinne, Sara S., Vorobyeva, Anzhelika, Tolmachev, Vladimir, Gräslund, Torbjörn, Orlova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721809/
https://www.ncbi.nlm.nih.gov/pubmed/31416167
http://dx.doi.org/10.3390/cancers11081168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721809/
https://www.ncbi.nlm.nih.gov/pubmed/31416167
http://dx.doi.org/10.3390/cancers11081168

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