RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5

The small GTPase RAC1B functions as a powerful inhibitor of transforming growth factor (TGF)-β1-induced epithelial-mesenchymal transition, cell motility, and growth arrest in pancreatic epithelial cells. Previous work has shown that RAC1B downregulates the TGF-β type I receptor ALK5, but the molecul...

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Detalles Bibliográficos
Autores principales: Otterbein, Hannah, Mihara, Koichiro, Hollenberg, Morley D., Lehnert, Hendrik, Witte, David, Ungefroren, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721813/
https://www.ncbi.nlm.nih.gov/pubmed/31434318
http://dx.doi.org/10.3390/cancers11081211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721813/
https://www.ncbi.nlm.nih.gov/pubmed/31434318
http://dx.doi.org/10.3390/cancers11081211

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