Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex

Insulin signaling controls metabolic homeostasis. Here, we report the cryo-EM structure of full-length insulin receptor (IR) and insulin complex in the active state. This structure unexpectedly reveals that maximally four insulins can bind the ‘T’-shaped IR dimer at four distinct sites related by 2-...

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Detalles Bibliográficos
Autores principales: Uchikawa, Emiko, Choi, Eunhee, Shang, Guijun, Yu, Hongtao, Bai, Xiao-chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721835/
https://www.ncbi.nlm.nih.gov/pubmed/31436533
http://dx.doi.org/10.7554/eLife.48630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721835/
https://www.ncbi.nlm.nih.gov/pubmed/31436533
http://dx.doi.org/10.7554/eLife.48630

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