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A junctophilin-caveolin interaction enables efficient coupling between ryanodine receptors and BK(Ca) channels in the Ca(2+) microdomain of vascular smooth muscle

Functional coupling between large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in the plasma membrane (PM) and ryanodine receptors (RyRs) in the sarcoplasmic reticulum (SR) is an essential mechanism for regulating mechanical force in most smooth muscle (SM) tissues. Spontaneous Ca(2+) release...

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Detalles Bibliográficos
Autores principales: Saeki, Takanori, Suzuki, Yoshiaki, Yamamura, Hisao, Takeshima, Hiroshi, Imaizumi, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721949/
https://www.ncbi.nlm.nih.gov/pubmed/31308177
http://dx.doi.org/10.1074/jbc.RA119.008342