C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene

Insulin interacts with the insulin receptor, and the activated receptor promotes activity of the phosphoinositide-3 kinase (PI3K) enzyme. A decrease in insulin or insulin-like growth factor 1 (IGF-1) signaling increases the lifespan in mammalian species. We found that a point mutation in the C-SH2 d...

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Detalles Bibliográficos
Autores principales: Kano, Yoshio, Hiragami, Fukumi, Motoda, Hirotoshi, Akiyama, Junichi, Koike, Yoshihisa, Gomita, Yutaka, Inoue, Shigeki, Kawaura, Akihiko, Furuta, Tomohisa, Kawamura, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722097/
https://www.ncbi.nlm.nih.gov/pubmed/31481652
http://dx.doi.org/10.1038/s41598-019-48157-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722097/
https://www.ncbi.nlm.nih.gov/pubmed/31481652
http://dx.doi.org/10.1038/s41598-019-48157-6

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