Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors

Secretory human carbonic anhydrase VI (CA VI) has emerged as a potential drug target due to its role in pathological states, such as excess acidity-caused dental caries and injuries of gastric epithelium. Currently, there are no available CA VI-selective inhibitors or crystallographic structures of...

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Detalles Bibliográficos
Autores principales: Kazokaitė, Justina, Kairys, Visvaldas, Smirnovienė, Joana, Smirnov, Alexey, Manakova, Elena, Tolvanen, Martti, Parkkila, Seppo, Matulis, Daumantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722136/
https://www.ncbi.nlm.nih.gov/pubmed/31481705
http://dx.doi.org/10.1038/s41598-019-49094-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722136/
https://www.ncbi.nlm.nih.gov/pubmed/31481705
http://dx.doi.org/10.1038/s41598-019-49094-0

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