Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

Tumor-associated macrophages (TAMs) usually express an M2 phenotype, which enables them to perform immunosuppressive and tumor-promoting functions. Reprogramming these TAMs toward an M1 phenotype could thwart their pro-cancer activities and unleash anti-tumor immunity, but efforts to accomplish this...

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Detalles Bibliográficos
Autores principales: Zhang, F., Parayath, N. N., Ene, C. I., Stephan, S. B., Koehne, A. L., Coon, M. E., Holland, E. C., Stephan, M. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722139/
https://www.ncbi.nlm.nih.gov/pubmed/31481662
http://dx.doi.org/10.1038/s41467-019-11911-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722139/
https://www.ncbi.nlm.nih.gov/pubmed/31481662
http://dx.doi.org/10.1038/s41467-019-11911-5

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