Ligand Binding Dynamics for Pre-dimerised G Protein-Coupled Receptor Homodimers: Linear Models and Analytical Solutions

Evidence suggests that many G protein-coupled receptors (GPCRs) are bound together forming dimers. The implications of dimerisation for cellular signalling outcomes, and ultimately drug discovery and therapeutics, remain unclear. Consideration of ligand binding and signalling via receptor dimers is...

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Detalles Bibliográficos
Autores principales: White, Carla, Bridge, Lloyd J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Special Issue: Mathematics to Support Drug Discovery and Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722261/
https://www.ncbi.nlm.nih.gov/pubmed/29349610
http://dx.doi.org/10.1007/s11538-017-0387-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722261/
https://www.ncbi.nlm.nih.gov/pubmed/29349610
http://dx.doi.org/10.1007/s11538-017-0387-x

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