The Early Phase of β2m Aggregation: An Integrative Computational Study Framed on the D76N Mutant and the ΔN6 Variant

Human β2-microglobulin (b2m) protein is classically associated with dialysis-related amyloidosis (DRA). Recently, the single point mutant D76N was identified as the causative agent of a hereditary systemic amyloidosis affecting visceral organs. To get insight into the early stage of the β2m aggregat...

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Detalles Bibliográficos
Autores principales: J. S. Loureiro, Rui, Vila-Viçosa, Diogo, Machuqueiro, Miguel, Shakhnovich, Eugene I., F. N. Faísca, Patrícia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722664/
https://www.ncbi.nlm.nih.gov/pubmed/31416179
http://dx.doi.org/10.3390/biom9080366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722664/
https://www.ncbi.nlm.nih.gov/pubmed/31416179
http://dx.doi.org/10.3390/biom9080366

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