Are Inositol Polyphosphates the Missing Link in Dynamic Cullin RING Ligase Regulation by the COP9 Signalosome?

The E3 ligase activity of Cullin RING Ligases (CRLs) is controlled by cycles of neddylation/deneddylation and intimately regulated by the deneddylase COP9 Signalosome (CSN), one of the proteasome lid-CSN-initiation factor 3 (PCI) domain-containing “Zomes” complex. Besides catalyzing the removal of s...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaozhe, Rao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722667/
https://www.ncbi.nlm.nih.gov/pubmed/31394817
http://dx.doi.org/10.3390/biom9080349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722667/
https://www.ncbi.nlm.nih.gov/pubmed/31394817
http://dx.doi.org/10.3390/biom9080349

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