Cargando…

Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D(2) Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor

The interplay between the dopamine (DA) and opioid systems in the brain is known to modulate the additive effects of substances of abuse. On one hand, opioids serve mankind by their analgesic properties, which are mediated via the mu opioid receptor (MOR), a Class A G protein-coupled receptor (GPCR)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vasudevan, Lakshmi, Borroto-Escuela, Dasiel O., Huysentruyt, Jelle, Fuxe, Kjell, Saini, Deepak K., Stove, Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722706/ https://www.ncbi.nlm.nih.gov/pubmed/31416253 http://dx.doi.org/10.3390/biom9080368

Ejemplares similares

The mGlu(5) Receptor Protomer-Mediated Dopamine D(2) Receptor Trans-Inhibition Is Dependent on the Adenosine A(2A) Receptor Protomer: Implications for Parkinson’s Disease
por: Romero-Fernandez, Wilber, et al.
Publicado: (2022)

Oligomeric Receptor Complexes and Their Allosteric Receptor-Receptor Interactions in the Plasma Membrane Represent a New Biological Principle for Integration of Signals in the CNS
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

Volume transmission and receptor-receptor interactions in heteroreceptor complexes: understanding the role of new concepts for brain communication
por: Fuxe, Kjell, et al.
Publicado: (2016)

Can Allosteric Receptor-Protein Interactions in Receptor Complexes Be a Molecular Mechanism Involved in Cancer Immune Therapy?
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

On the G Protein-Coupled Receptor Neuromodulation of the Claustrum
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

The Balance of MU-Opioid, Dopamine D2 and Adenosine A2A Heteroreceptor Complexes in the Ventral Striatal-Pallidal GABA Antireward Neurons May Have a Significant Role in Morphine and Cocaine Use Disorders
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2021)

The integrative role of G protein-coupled receptor heterocomplexes in Parkinson’s disease
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2022)

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonists
por: Murányi, Marianna, et al.
Publicado: (2013)

Dopamine D(4) Receptor Counteracts Morphine-Induced Changes in μ Opioid Receptor Signaling in the Striosomes of the Rat Caudate Putamen
por: Suárez-Boomgaard, Diana, et al.
Publicado: (2014)

An Emerging Role for the Delta Opioid Receptor in the Regulation of Mu Opioid Receptor Function
por: Rozenfeld, Raphael, et al.
Publicado: (2007)

Orvinols with Mixed Kappa/Mu Opioid Receptor Agonist Activity
por: Greedy, Benjamin M., et al.
Publicado: (2013)

Evidence for the existence of dopamine D2R and Sigma 1 allosteric receptor-receptor interaction in the rat brain: role in brain plasticity and cocaine action
por: Pinton, Luca, et al.
Publicado: (2015)

Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy
por: Olson, Keith M., et al.
Publicado: (2023)

Recent Molecular Insights into Agonist-specific Binding to the Mu-Opioid Receptor
por: Zádor, Ferenc, et al.
Publicado: (2022)

Mu Opioid Receptor Actions in the Lateral Habenula
por: Margolis, Elyssa B., et al.
Publicado: (2016)

Effects of mu- and kappa-2 opioid receptor agonists on pain and rearing behaviors
por: Neubert, John K, et al.
Publicado: (2007)

Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self-administration through Nociceptin Opioid and Mu Opioid Receptors
por: Shen, Qianwei, et al.
Publicado: (2017)

Activity of opioid ligands in cells expressing cloned mu opioid receptors
por: Gharagozlou, Parham, et al.
Publicado: (2003)

Mu Opioid Receptor Gene: New Point Mutations in Opioid Addicts
por: Dinarvand, Amin, et al.
Publicado: (2014)

It’s MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system
por: Chartoff, Elena H., et al.
Publicado: (2014)

Diversity and Bias through Receptor–Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization
por: Fuxe, Kjell, et al.
Publicado: (2014)

Mu opioid receptor: from pain to glucose metabolism
por: Tudurí, Eva, et al.
Publicado: (2016)

On the role of A(2A) and D(2) receptors in control of cocaine and food-seeking behaviors in rats
por: Wydra, Karolina, et al.
Publicado: (2014)

Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson’s disease and its treatment
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2019)

Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, OPRM1: Insight into Complex Mu Opioid Actions
por: Liu, Shan, et al.
Publicado: (2021)

Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists
por: Kaserer, Teresa, et al.
Publicado: (2020)

Molecular signatures of mu opioid receptor and somatostatin receptor 2 in pancreatic cancer
por: Jorand, Raphael, et al.
Publicado: (2016)

Molecular Perspectives for mu/delta Opioid Receptor Heteromers as Distinct, Functional Receptors
por: Ong, Edmund W., et al.
Publicado: (2014)

Differential Stability of the Crystallographic Interfaces of Mu- and Kappa-Opioid Receptors
por: Johnston, Jennifer M., et al.
Publicado: (2014)

Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons
por: Ehrlich, Aliza T., et al.
Publicado: (2019)

Heteromerization Modulates mu Opioid Receptor Functional Properties in vivo
por: Ugur, Muzeyyen, et al.
Publicado: (2018)

Blocking mu-opioid receptors inhibits social bonding in rituals
por: Charles, S. J., et al.
Publicado: (2020)

Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction?
por: Belltall, Amparo, et al.
Publicado: (2022)

Functional selectivity of EM-2 analogs at the mu-opioid receptor
por: Piekielna-Ciesielska, Justyna, et al.
Publicado: (2023)

Comparison of physicochemical properties and biological activities of opioid morphinans interacting with mu opioid receptors
por: Asim, Muhammad F, et al.
Publicado: (2008)

Role of kappa‐opioid and mu‐opioid receptors in pruritus: Peripheral and central itch circuits
por: Kim, Brian S., et al.
Publicado: (2022)

Differential allosteric modulation within dopamine D(2)R - neurotensin NTS1R and D(2)R - serotonin 5-HT(2A)R receptor complexes gives bias to intracellular calcium signalling
por: Plach, Michael, et al.
Publicado: (2019)

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera
por: Guillemyn, Karel, et al.
Publicado: (2012)

On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System: Focus on Their Role in Pain Modulation
por: Borroto-Escuela, Dasiel O., et al.
Publicado: (2013)

Analgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery
por: Li, Guangwen, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_9ebp28rrmn9pdnhsrkh8vibai5