Cargando…

Analytical and Computational Methods for the Estimation of Drug-Polymer Solubility and Miscibility in Solid Dispersions Development

The development of stable solid dispersion formulations that maintain desired improvement of drug dissolution rate during the entire shelf life requires the analysis of drug-polymer solubility and miscibility. Only if the drug concentration is below the solubility limit in the polymer, the physical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Medarević, Djordje, Djuriš, Jelena, Barmpalexis, Panagiotis, Kachrimanis, Kyriakos, Ibrić, Svetlana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722809/ https://www.ncbi.nlm.nih.gov/pubmed/31374926 http://dx.doi.org/10.3390/pharmaceutics11080372

Ejemplares similares

Development of ternary solid dispersions with hydrophilic polymer and surface adsorbent for improving dissolution rate of carbamazepine
por: Vojinović, Tanja, et al.
Publicado: (2018)

Improving Tableting Performance of Lactose Monohydrate by Fluid-Bed Melt Granulation Co-Processing
por: Medarević, Djordje, et al.
Publicado: (2021)

Insight into the Formation of Glimepiride Nanocrystals by Wet Media Milling
por: Medarević, Djordje, et al.
Publicado: (2020)

Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process
por: Djuriš, Jelena, et al.
Publicado: (2012)

Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press
por: Krivokapić, Jovana, et al.
Publicado: (2020)

Optimization and Prediction of Ibuprofen Release from 3D DLP Printlets Using Artificial Neural Networks
por: Madzarevic, Marijana, et al.
Publicado: (2019)

Artificial Neural Networks in Evaluation and Optimization of Modified Release Solid Dosage Forms
por: Ibrić, Svetlana, et al.
Publicado: (2012)

Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery
por: Karagianni, Anna, et al.
Publicado: (2018)

Preparation and Evaluation of Amorphous Solid Dispersions for Enhancing Luteolin’s Solubility in Simulated Saliva
por: Koromili, Maria, et al.
Publicado: (2022)

Unravelling the Miscibility of Poly(2-oxazoline)s: A Novel Polymer Class for the Formulation of Amorphous Solid Dispersions
por: Everaerts, Melissa, et al.
Publicado: (2020)

Application of Machine-Learning Algorithms for Better Understanding of Tableting Properties of Lactose Co-Processed with Lipid Excipients
por: Djuris, Jelena, et al.
Publicado: (2021)

Polyelectrolyte Matrices in the Modulation of Intermolecular Electrostatic Interactions for Amorphous Solid Dispersions: A Comprehensive Review
por: Tsiaxerli, Anastasia, et al.
Publicado: (2021)

Hot Melt Extruded Amorphous Solid Dispersion of Posaconazole with Improved Bioavailability: Investigating Drug-Polymer Miscibility with Advanced Characterisation
por: Fule, Ritesh, et al.
Publicado: (2014)

Digital Light Processing (DLP) 3D Printing of Atomoxetine Hydrochloride Tablets Using Photoreactive Suspensions
por: Krkobabić, Mirjana, et al.
Publicado: (2020)

Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading
por: Stanojević, Gordana, et al.
Publicado: (2020)

Molecular Simulation and Statistical Learning Methods toward Predicting Drug–Polymer Amorphous Solid Dispersion Miscibility, Stability, and Formulation Design
por: Walden, Daniel M., et al.
Publicado: (2021)

Atomic Force Microscopy-Based Screening of Drug-Excipient Miscibility and Stability of Solid Dispersions
por: Lauer, Matthias Eckhard, et al.
Publicado: (2010)

Miscibility and Solubility of Caffeine and Theophylline in Hydroxypropyl Methylcellulose
por: Leyk, Edyta, et al.
Publicado: (2021)

Understanding the Effect of Energy Density and Formulation Factors on the Printability and Characteristics of SLS Irbesartan Tablets—Application of the Decision Tree Model
por: Madžarević, Marijana, et al.
Publicado: (2021)

A Novel Rheological Method to Assess Drug-Polymer Interactions Regarding Miscibility and Crystallization of Drug in Amorphous Solid Dispersions for Oral Drug Delivery
por: Tsakiridou, Georgia, et al.
Publicado: (2019)

Utilizing Drug Amorphous Solid Dispersions for the Preparation of Dronedarone per os Formulations
por: Kapourani, Afroditi, et al.
Publicado: (2023)

A simple approach to polymer mixture miscibility
por: Higgins, Julia S., et al.
Publicado: (2010)

An Insight into the Solid-State Miscibility of Triacylglycerol Crystals
por: Macridachis-González, Jorge, et al.
Publicado: (2020)

Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability
por: Krstić, Marko, et al.
Publicado: (2015)

Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
por: Karagianni, Anna, et al.
Publicado: (2018)

Drug crystal growth in ternary amorphous solid dispersions: Effect of surfactants and polymeric matrix-carriers
por: Kapourani, Afroditi, et al.
Publicado: (2021)

Determination of the physical state of a drug in amorphous solid dispersions using artificial neural networks and ATR-FTIR spectroscopy
por: Kapourani, Afroditi, et al.
Publicado: (2020)

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs
por: Tran, Thao T.D., et al.
Publicado: (2020)

Nanoscale Restructuring of Polymer Materials to Produce Single Polymer Composites and Miscible Blends
por: Tonelli, Alan E.
Publicado: (2019)

Conformational Entropy Contributions to the Glass Temperature of Blends of Miscible Polymers
por: Schneider, Hans Adam
Publicado: (1997)

Spatially and Temporally Resolved Heterogeneities in a Miscible Polymer Blend
por: Zhang, Guofeng, et al.
Publicado: (2020)

The miscibility and spatial distribution of the components in electrospun polymer–protein mats
por: Pavlova, Elizaveta, et al.
Publicado: (2020)

Drug Amorphous Solid Dispersions Based on Poly(vinyl Alcohol): Evaluating the Effect of Poly(propylene Succinate) as Plasticizer
por: Kapourani, Afroditi, et al.
Publicado: (2021)

Solubility enhancement of some poorly soluble drugs by solid dispersion using Ziziphus spina-christi gum polymer
por: Alwossabi, Ameen M., et al.
Publicado: (2022)

Cefdinir Solid Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility, Dissolution, and Bioavailability in Rats
por: Cho, Hyun-Jong, et al.
Publicado: (2017)

Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion–Melt Dispersion Technique
por: Mudrić, Jelena, et al.
Publicado: (2021)

Controlling Miscibility of the Interphase in Polymer-Grafted Nanocellulose/Cellulose Triacetate Nanocomposites
por: Soeta, Hiroto, et al.
Publicado: (2020)

Improvement in solubility of poor water-soluble drugs by solid dispersion
por: Sareen, Swati, et al.
Publicado: (2012)

Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal Formulation
por: Ouranidis, Andreas, et al.
Publicado: (2020)

Constraining Polymers into β-Turns: Miscibility and Phase Segregation Effects in Lipid Monolayers
por: Deike, Stefanie, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_838eq9k75nvilb35v5searj01q