C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X‐interacting protein (HBXIP; LAMTOR 1—5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 signaling. Here, we present the crystal structure of human HBXIP‐C7orf59 dimer...

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Detalles Bibliográficos
Autores principales: Rasheed, Nadia, Lima, Tatiani B., Mercaldi, Gustavo F., Nascimento, Andrey F.Z., Silva, Ana L.S., Righetto, Germanna L., Bar‐Peled, Liron, Shen, Kuang, Sabatini, David M., Gozzo, Fabio C., Aparicio, Ricardo, Smetana, Juliana H.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722880/
https://www.ncbi.nlm.nih.gov/pubmed/31314152
http://dx.doi.org/10.1002/2211-5463.12700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722880/
https://www.ncbi.nlm.nih.gov/pubmed/31314152
http://dx.doi.org/10.1002/2211-5463.12700

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