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Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. We studied the effects of chronic consumption of extra virgin olive oil (EVOO), enriched in bioactive compounds from olive fruit and leaves, on blood pressure,...

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Autores principales: Vazquez, Alejandra, Sanchez-Rodriguez, Estefania, Vargas, Félix, Montoro-Molina, Sebastián, Romero, Miguel, Espejo-Calvo, Juan Antonio, Vilchez, Pedro, Jaramillo, Sara, Olmo-García, Lucía, Carrasco-Pancorbo, Alegría, de la Torre, Rafael, Fito, Montserrat, Covas, María-Isabel, Martínez de Victoria, Emilio, Mesa, Maria Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722946/
https://www.ncbi.nlm.nih.gov/pubmed/31357464
http://dx.doi.org/10.3390/nu11081728
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author Vazquez, Alejandra
Sanchez-Rodriguez, Estefania
Vargas, Félix
Montoro-Molina, Sebastián
Romero, Miguel
Espejo-Calvo, Juan Antonio
Vilchez, Pedro
Jaramillo, Sara
Olmo-García, Lucía
Carrasco-Pancorbo, Alegría
de la Torre, Rafael
Fito, Montserrat
Covas, María-Isabel
Martínez de Victoria, Emilio
Mesa, Maria Dolores
author_facet Vazquez, Alejandra
Sanchez-Rodriguez, Estefania
Vargas, Félix
Montoro-Molina, Sebastián
Romero, Miguel
Espejo-Calvo, Juan Antonio
Vilchez, Pedro
Jaramillo, Sara
Olmo-García, Lucía
Carrasco-Pancorbo, Alegría
de la Torre, Rafael
Fito, Montserrat
Covas, María-Isabel
Martínez de Victoria, Emilio
Mesa, Maria Dolores
author_sort Vazquez, Alejandra
collection PubMed
description Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. We studied the effects of chronic consumption of extra virgin olive oil (EVOO), enriched in bioactive compounds from olive fruit and leaves, on blood pressure, endothelial function, oxidative and inflammatory status, and circulating cholesterol levels, in spontaneously hypertensive rats (SHR). Thirty SHR were randomly assigned to three groups: a control untreated SHR group, an SHR group (1 mL/rat/day) of a control olive oil (17.6 mg/kg of phenolic compounds), and an SHR group (1 mL/rat/day) of the enriched EVOO (750 mg/kg of phenolic compounds) for eight weeks. Ten Wistar Kyoto rats (WKY) were included as healthy controls. Long-term administration of the enriched EVOO decreased systolic blood pressure and cardiac hypertrophy, and improved the ex vivo aortic endothelial dysfunction measured in SHR. Moreover, enriched oil supplementation reduced the plasma levels of Angiotensin II and total cholesterol, and the urinary levels of endothelin-1 and oxidative stress biomarkers, while pro-inflammatory cytokines were unaffected. In conclusion, sustained treatment with EVOO, enriched in bioactive compounds from the olive fruit and leaves, may be an effective tool for reducing blood pressure and cholesterol levels alone or in combination with pharmacological anti-hypertensive treatment.
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spelling pubmed-67229462019-09-10 Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats Vazquez, Alejandra Sanchez-Rodriguez, Estefania Vargas, Félix Montoro-Molina, Sebastián Romero, Miguel Espejo-Calvo, Juan Antonio Vilchez, Pedro Jaramillo, Sara Olmo-García, Lucía Carrasco-Pancorbo, Alegría de la Torre, Rafael Fito, Montserrat Covas, María-Isabel Martínez de Victoria, Emilio Mesa, Maria Dolores Nutrients Article Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. We studied the effects of chronic consumption of extra virgin olive oil (EVOO), enriched in bioactive compounds from olive fruit and leaves, on blood pressure, endothelial function, oxidative and inflammatory status, and circulating cholesterol levels, in spontaneously hypertensive rats (SHR). Thirty SHR were randomly assigned to three groups: a control untreated SHR group, an SHR group (1 mL/rat/day) of a control olive oil (17.6 mg/kg of phenolic compounds), and an SHR group (1 mL/rat/day) of the enriched EVOO (750 mg/kg of phenolic compounds) for eight weeks. Ten Wistar Kyoto rats (WKY) were included as healthy controls. Long-term administration of the enriched EVOO decreased systolic blood pressure and cardiac hypertrophy, and improved the ex vivo aortic endothelial dysfunction measured in SHR. Moreover, enriched oil supplementation reduced the plasma levels of Angiotensin II and total cholesterol, and the urinary levels of endothelin-1 and oxidative stress biomarkers, while pro-inflammatory cytokines were unaffected. In conclusion, sustained treatment with EVOO, enriched in bioactive compounds from the olive fruit and leaves, may be an effective tool for reducing blood pressure and cholesterol levels alone or in combination with pharmacological anti-hypertensive treatment. MDPI 2019-07-26 /pmc/articles/PMC6722946/ /pubmed/31357464 http://dx.doi.org/10.3390/nu11081728 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vazquez, Alejandra
Sanchez-Rodriguez, Estefania
Vargas, Félix
Montoro-Molina, Sebastián
Romero, Miguel
Espejo-Calvo, Juan Antonio
Vilchez, Pedro
Jaramillo, Sara
Olmo-García, Lucía
Carrasco-Pancorbo, Alegría
de la Torre, Rafael
Fito, Montserrat
Covas, María-Isabel
Martínez de Victoria, Emilio
Mesa, Maria Dolores
Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats
title Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats
title_full Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats
title_fullStr Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats
title_full_unstemmed Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats
title_short Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats
title_sort cardioprotective effect of a virgin olive oil enriched with bioactive compounds in spontaneously hypertensive rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722946/
https://www.ncbi.nlm.nih.gov/pubmed/31357464
http://dx.doi.org/10.3390/nu11081728
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