Mitochondrial DNA Variants in Patients with Liver Injury Due to Anti-Tuberculosis Drugs

Background: Hepatotoxicity is the most severe adverse effect of anti-tuberculosis therapy. Isoniazid’s metabolite hydrazine is a mitochondrial complex II inhibitor. We hypothesized that mitochondrial DNA variants are risk factors for drug-induced liver injury (DILI) due to isoniazid, rifampicin or p...

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Detalles Bibliográficos
Autores principales: Lee, Li-Na, Huang, Chun-Ta, Hsu, Chia-Lin, Chang, Hsiu-Ching, Jan, I-Shiow, Liu, Jia-Luen, Sheu, Jin-Chuan, Wang, Jann-Tay, Liu, Wei-Lun, Wu, Huei-Shu, Chang, Ching-Nien, Wang, Jann-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723168/
https://www.ncbi.nlm.nih.gov/pubmed/31412578
http://dx.doi.org/10.3390/jcm8081207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723168/
https://www.ncbi.nlm.nih.gov/pubmed/31412578
http://dx.doi.org/10.3390/jcm8081207

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