Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

Tacrine was the first drug to be approved for Alzheimer’s disease (AD) treatment, acting as a cholinesterase inhibitor. The neuropathological hallmarks of AD are amyloid-rich senile plaques, neurofibrillary tangles, and neuronal degeneration. The portfolio of currently approved drugs for AD includes...

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Detalles Bibliográficos
Autores principales: Svobodova, Barbora, Mezeiova, Eva, Hepnarova, Vendula, Hrabinova, Martina, Muckova, Lubica, Kobrlova, Tereza, Jun, Daniel, Soukup, Ondrej, Jimeno, María Luisa, Marco-Contelles, José, Korabecny, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723352/
https://www.ncbi.nlm.nih.gov/pubmed/31430943
http://dx.doi.org/10.3390/biom9080379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723352/
https://www.ncbi.nlm.nih.gov/pubmed/31430943
http://dx.doi.org/10.3390/biom9080379

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