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Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese

The role of diet and circulatory carotenoids and docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are implicated in age-related macular degeneration (AMD) but not well studied in Chinese. However, other fatty acids were not comprehensively evaluated if it had additional consequence on AMD....

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Autores principales: Ng, Alex L.-K., Leung, Ho Hang, Kawasaki, Ryo, Ho, Wing-Lau, Chow, Loraine L.-W., Chow, Sharon S.-W., Lee, Jetty Chung-Yung, Wong, Ian Y.-H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723701/
https://www.ncbi.nlm.nih.gov/pubmed/31349710
http://dx.doi.org/10.3390/nu11081720
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author Ng, Alex L.-K.
Leung, Ho Hang
Kawasaki, Ryo
Ho, Wing-Lau
Chow, Loraine L.-W.
Chow, Sharon S.-W.
Lee, Jetty Chung-Yung
Wong, Ian Y.-H.
author_facet Ng, Alex L.-K.
Leung, Ho Hang
Kawasaki, Ryo
Ho, Wing-Lau
Chow, Loraine L.-W.
Chow, Sharon S.-W.
Lee, Jetty Chung-Yung
Wong, Ian Y.-H.
author_sort Ng, Alex L.-K.
collection PubMed
description The role of diet and circulatory carotenoids and docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are implicated in age-related macular degeneration (AMD) but not well studied in Chinese. However, other fatty acids were not comprehensively evaluated if it had additional consequence on AMD. This study investigated the relationship among dietary habits, fatty acids levels, carotenoids and AMD in Hong Kong Chinese adults. In this cross-sectional case-controlled study, plasma fatty acids including, saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and carotenoids levels were quantified between patients with neovascular AMD (n = 99) and age-gender-matched controls (n = 198). A food frequency questionnaire was also conducted. Low blood carotenoid levels and omega-3 PUFAs namely DHA, EPA and α-linolenic acid increased the odds ratio of developing neovascular AMD. High blood omega-6 PUFAs specifically arachidonic acid and eicosadienoic acid, oleic acid (a MUFA) and SFA levels increased the odds ratio of having neovascular AMD. Neovascular AMD group had significantly less omega-3 PUFA rich food (vegetables, nuts, seafood) intake and higher SFA (meat) intake than controls. In short, neovascular AMD was associated with lower circulatory levels of carotenoids and omega-3 PUFAs, and higher level of omega-6 PUFAs, oleic acid and SFAs in the Hong Kong Chinese population. These findings enhance the understandings of dietary impacts on neovascular AMD and provide a context for future nutritional intervention studies.
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spelling pubmed-67237012019-09-10 Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese Ng, Alex L.-K. Leung, Ho Hang Kawasaki, Ryo Ho, Wing-Lau Chow, Loraine L.-W. Chow, Sharon S.-W. Lee, Jetty Chung-Yung Wong, Ian Y.-H. Nutrients Article The role of diet and circulatory carotenoids and docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are implicated in age-related macular degeneration (AMD) but not well studied in Chinese. However, other fatty acids were not comprehensively evaluated if it had additional consequence on AMD. This study investigated the relationship among dietary habits, fatty acids levels, carotenoids and AMD in Hong Kong Chinese adults. In this cross-sectional case-controlled study, plasma fatty acids including, saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), and carotenoids levels were quantified between patients with neovascular AMD (n = 99) and age-gender-matched controls (n = 198). A food frequency questionnaire was also conducted. Low blood carotenoid levels and omega-3 PUFAs namely DHA, EPA and α-linolenic acid increased the odds ratio of developing neovascular AMD. High blood omega-6 PUFAs specifically arachidonic acid and eicosadienoic acid, oleic acid (a MUFA) and SFA levels increased the odds ratio of having neovascular AMD. Neovascular AMD group had significantly less omega-3 PUFA rich food (vegetables, nuts, seafood) intake and higher SFA (meat) intake than controls. In short, neovascular AMD was associated with lower circulatory levels of carotenoids and omega-3 PUFAs, and higher level of omega-6 PUFAs, oleic acid and SFAs in the Hong Kong Chinese population. These findings enhance the understandings of dietary impacts on neovascular AMD and provide a context for future nutritional intervention studies. MDPI 2019-07-25 /pmc/articles/PMC6723701/ /pubmed/31349710 http://dx.doi.org/10.3390/nu11081720 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ng, Alex L.-K.
Leung, Ho Hang
Kawasaki, Ryo
Ho, Wing-Lau
Chow, Loraine L.-W.
Chow, Sharon S.-W.
Lee, Jetty Chung-Yung
Wong, Ian Y.-H.
Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese
title Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese
title_full Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese
title_fullStr Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese
title_full_unstemmed Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese
title_short Dietary Habits, Fatty Acids and Carotenoid Levels Are Associated with Neovascular Age-Related Macular Degeneration in Chinese
title_sort dietary habits, fatty acids and carotenoid levels are associated with neovascular age-related macular degeneration in chinese
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723701/
https://www.ncbi.nlm.nih.gov/pubmed/31349710
http://dx.doi.org/10.3390/nu11081720
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