Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability

Genetic activation of the class I PI3K pathway is very common in cancer. This mostly results from oncogenic mutations in PIK3CA, the gene encoding the ubiquitously expressed PI3Kα catalytic subunit, or from inactivation of the PTEN tumour suppressor, a lipid phosphatase that opposes class I PI3K sig...

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Detalles Bibliográficos
Autores principales: Vanhaesebroeck, Bart, Bilanges, Benoit, Madsen, Ralitsa R., Dale, Katie L., Lau, Evelyn, Vladimirou, Elina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723836/
https://www.ncbi.nlm.nih.gov/pubmed/31374965
http://dx.doi.org/10.3390/biom9080331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723836/
https://www.ncbi.nlm.nih.gov/pubmed/31374965
http://dx.doi.org/10.3390/biom9080331

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