The Anticancer Agent Elesclomol Has Direct Effects on Mitochondrial Bioenergetic Function in Isolated Mammalian Mitochondria

Elesclomol ((N-malonyl-bis(N′-methyl-N′-thiobenzoylhydrazide)); formerly STA-4783) is a mitochondria-targeted chemotherapeutic agent that has demonstrated efficacy in selective cancer cell killing in pre-clinical and clinical testing. The biologically active form of elesclomol is a deprotonated copp...

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Detalles Bibliográficos
Autores principales: Modica-Napolitano, Josephine S., Bharath, Leena P., Hanlon, Alison J., Hurley, Liam D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724019/
https://www.ncbi.nlm.nih.gov/pubmed/31344923
http://dx.doi.org/10.3390/biom9080298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724019/
https://www.ncbi.nlm.nih.gov/pubmed/31344923
http://dx.doi.org/10.3390/biom9080298

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