Cargando…

Biotransformation of the Mycotoxin Enniatin B1 by CYP P450 3A4 and Potential for Drug-Drug Interactions

Enniatins (ENNs) are fungal secondary metabolites that frequently occur in grain in temperate climates. Their toxic potency is connected to their ionophoric character and lipophilicity. The biotransformation of ENNs predominantly takes place via cytochrome P450 3A (CYP 3A)-dependent oxidation reacti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ivanova, Lada, Denisov, Ilia G., Grinkova, Yelena V., Sligar, Stephen G., Fæste, Christiane K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724072/ https://www.ncbi.nlm.nih.gov/pubmed/31357617 http://dx.doi.org/10.3390/metabo9080158

Ejemplares similares

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by CYP3A4
por: Denisov, Ilia G., et al.
Publicado: (2022)

In Vitro Toxicokinetics and Phase I Biotransformation of the Mycotoxin Penitrem A in Dogs
por: Uhlig, Silvio, et al.
Publicado: (2020)

Atlantic Salmon Gill Epithelial Cell Line (ASG-10) as a Suitable Model for Xenobiotic Biotransformation
por: Ivanova, Lada, et al.
Publicado: (2023)

A Review of the Mycotoxin Enniatin B
por: Prosperini, Alessandra, et al.
Publicado: (2017)

Feedborne Mycotoxins Beauvericin and Enniatins and Livestock Animals
por: Křížová, Ludmila, et al.
Publicado: (2021)

Enniatin B1: Emerging Mycotoxin and Emerging Issues
por: De Felice, Beatrice, et al.
Publicado: (2023)

Emerging Fusarium Mycotoxins Fusaproliferin, Beauvericin, Enniatins, and Moniliformin in Serbian Maize
por: Jajić, Igor, et al.
Publicado: (2019)

Drug-drug interactions: it is not only CYP450's which matter
por: Back, David J
Publicado: (2010)

Development and Validation of a Liquid Chromatography High-Resolution Mass Spectrometry Method for the Simultaneous Determination of Mycotoxins and Phytoestrogens in Plant-Based Fish Feed and Exposed Fish
por: Johny, Amritha, et al.
Publicado: (2019)

Evaluation of Emerging Fusarium mycotoxins beauvericin, Enniatins, Fusaproliferin and Moniliformin in Domestic Rice in Iran
por: Nazari, Firouzeh, et al.
Publicado: (2015)

Detoxification of Mycotoxins through Biotransformation
por: Li, Peng, et al.
Publicado: (2020)

In vitro hepatic biotransformation of the algal toxin pectenotoxin-2
por: Sandvik, Morten, et al.
Publicado: (2020)

Nanodiscs as a therapeutic delivery agent: inhibition of respiratory syncytial virus infection in the lung
por: Numata, Mari, et al.
Publicado: (2013)

Sequence Divergence of the Enniatin Synthase Gene in Relation to Production of Beauvericin and Enniatins in Fusarium Species
por: Stępień, Łukasz, et al.
Publicado: (2013)

CYP450 drug inducibility in NAFLD via an in vitro hepatic model: Understanding drug-drug interactions in the fatty liver
por: Rey-Bedon, Camilo, et al.
Publicado: (2022)

Untargeted Metabolomics Approach Correlated Enniatin B Mycotoxin Presence in Cereals with Kashin–Beck Disease Endemic Regions of China
por: Sun, Danlei, et al.
Publicado: (2023)

Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice
por: Deodhar, Malavika, et al.
Publicado: (2020)

A systematic literature review on the effects of mycotoxin exposure on insects and on mycotoxin accumulation and biotransformation
por: Niermans, K., et al.
Publicado: (2021)

The Role of CYP450 Drug Metabolism in Precision Cardio-Oncology
por: Fatunde, Olubadewa A., et al.
Publicado: (2020)

Pre-clinical drug-drug interaction (DDI) of gefitinib or erlotinib with Cytochrome P450 (CYP) inhibiting drugs, fluoxetine and/or losartan
por: Luong, Thu-Lan T., et al.
Publicado: (2021)

Development of a Rapid LC-MS/MS Method for the Determination of Emerging Fusarium mycotoxins Enniatins and Beauvericin in Human Biological Fluids
por: Serrano, Ana Belén, et al.
Publicado: (2015)

Beauvericin and Enniatins: In Vitro Intestinal Effects
por: Bertero, Alessia, et al.
Publicado: (2020)

Potential Metabolic Drug–Drug Interaction of Citrus aurantium L. (Rutaceae) Evaluating by Its Effect on 3 CYP450
por: Zhou, Lu, et al.
Publicado: (2018)

SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions
por: Preissner, Saskia, et al.
Publicado: (2010)

In Silico Prediction of Cytochrome P450-Drug Interaction: QSARs for CYP3A4 and CYP2C9
por: Nembri, Serena, et al.
Publicado: (2016)

Investigating the Efficiency of Hydroxycinnamic Acids to Inhibit the Production of Enniatins by Fusarium avenaceum and Modulate the Expression of Enniatins Biosynthetic Genes
por: Gautier, Charlotte, et al.
Publicado: (2020)

Mycotoxin Biotransformation by Native and Commercial Enzymes: Present and Future Perspectives
por: Loi, Martina, et al.
Publicado: (2017)

Computer-Aided (In Silico) Modeling of Cytochrome P450-Mediated Food–Drug Interactions (FDI)
por: Guttman, Yelena, et al.
Publicado: (2022)

Characterization of the Pharmacokinetics of Vilaprisan: Bioavailability, Excretion, Biotransformation, and Drug–Drug Interaction Potential
por: Schultze-Mosgau, Marcus-Hillert, et al.
Publicado: (2018)

Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells
por: Krug, Isabel, et al.
Publicado: (2018)

Ring-Oxidative Biotransformation and Drug Interactions of Propofol in the Livers of Rats
por: Tai, Yu-Ting, et al.
Publicado: (2015)

Interactions of Mycotoxin Alternariol with Cytochrome P450 Enzymes and OATP Transporters
por: Fliszár-Nyúl, Eszter, et al.
Publicado: (2022)

Mycotoxins: Biotransformation and Bioavailability Assessment Using Caco-2 Cell Monolayer
por: Tran, Van Nguyen, et al.
Publicado: (2020)

Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance
por: Yang, Yiting, et al.
Publicado: (2020)

Identification and cross-species comparison of in vitro phase I brevetoxin (BTX-2) metabolites in northern Gulf of Mexico fish and human liver microsomes by UHPLC-HRMS(/MS)
por: Gwinn, Jessica Kay, et al.
Publicado: (2023)

In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor
por: Zhang, Heather, et al.
Publicado: (2021)

Influence of Transmembrane Helix Mutations on Cytochrome P450-Membrane Interactions and Function
por: Mustafa, Ghulam, et al.
Publicado: (2019)

Drugs impact on CYP-450 enzyme family: A pharmacogenetical study of response variation
por: Kalra, Kapil, et al.
Publicado: (2009)

Biotransformation of the Mycotoxin Deoxynivalenol in Fusarium Resistant and Susceptible Near Isogenic Wheat Lines
por: Kluger, Bernhard, et al.
Publicado: (2015)

Differing Membrane Interactions of Two Highly Similar Drug-Metabolizing Cytochrome P450 Isoforms: CYP 2C9 and CYP 2C19
por: Mustafa, Ghulam, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3vlac4qli3aa4dkeff2h1t0avl