The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells

Compared to naïve B cells (NBCs), both B cell antigen receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells (GCBCs) to optimize selection for high-affinity B cells. The mechanism for BCR reprogramming in GCBCs remains unknown. We describe a GC-specific, AKT kinase-driven nega...

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Detalles Bibliográficos
Autores principales: Luo, Wei, Hawse, William, Conter, Laura, Trivedi, Nikita, Weisel, Florian, Wikenheiser, Daniel, Cattley, Richard T., Shlomchik, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724213/
https://www.ncbi.nlm.nih.gov/pubmed/31011187
http://dx.doi.org/10.1038/s41590-019-0376-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724213/
https://www.ncbi.nlm.nih.gov/pubmed/31011187
http://dx.doi.org/10.1038/s41590-019-0376-3

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