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The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells
Compared to naïve B cells (NBCs), both B cell antigen receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells (GCBCs) to optimize selection for high-affinity B cells. The mechanism for BCR reprogramming in GCBCs remains unknown. We describe a GC-specific, AKT kinase-driven nega...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724213/ https://www.ncbi.nlm.nih.gov/pubmed/31011187 http://dx.doi.org/10.1038/s41590-019-0376-3 |